From 2001 until 2003, she presented Finger Tips, an arts and crafts programme for children, which she co-presented with Stephen Mulhern.
She left in 2000, to concentrate on her other projects with CITV, including Draw Your Own Toons and Mouse, aimed at encouraging children to use computers.
Cotton joined CBBC in 2001 to present children's science programme Eureka TV.
She has also made appearances in the CBBC show Only in America, alongside her good friend and fellow presenter Reggie Yates.
In 2006, Cotton presented the second series of Love Island with Patrick Kielty on ITV, taking over from Kelly Brook.
In August 2017 Cotton's ancestry was explored in the UK BBC TV series Who Do You Think You Are?
The accounts of her ancestors' lives revealed some mixed fortunes, but Cotton was pleased to have discovered family history tales that she would be able to pass on to her own children.The programme revealed that one of her paternal great-grandfathers, Evan Meredith, had been a Welsh coalminer who had endured prison as a conscientious objector to military service in WW1 and in later life became a respected pharmacist.On her maternal line, the episode found her ancestor, William Gilmour, from Northern Ireland, who strived to improve his lot in the world.In 2007, she took over from Ben Shephard as the host of The X Factor spin-off programme, The Xtra Factor on ITV2.She presented it for one series before resigning to work in America.The 52-year-old Good Morning Britain presenter made the seemingly jealous dig after she was nominated for an award.